SWELL1 Chloride Channel

Cell Volume Regulation and Beyound

Molecular Biology and Physiology of Ion Transport

Chloride is the most abundant free negatively charged ion in the body. Chloride channels are cell-membrane embedded proteins, allowing the movement of chloride in and out of the cells. Defects in chloride fluxes are responsible for many human disorders, including cystic fibrosis, one of the most common genetic disease. However, we know little about some of these mysterious gate-keepers. The Qiu Lab employs a multi-disciplinary approach including high-throughput functional genomics, cell and brain slice electrophysiology, biochemistry, and mouse genetics to discover novel ion channels, elucidate their physiological role, and aim to target them in diseases, including ischemic stroke, epilepsy and glioma.

Check out our new papers on SWELL1 in glia-neuron interaction in Neuron, and on the discovery, structures, and cellular function of a brand new PAC Proton-Activated Chloride channel in Science, Nature, and Cell Reports!