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Discovery of the Proton-Activated Chloride Channel

Ion Channels in Physiology and Disease

Our lab is dedicated to advancing the understanding of ion channels as fundamental regulators of cellular function and their roles in health and disease. By integrating cutting-edge techniques in functional genomics, structural biology, in vivo imaging, and electrophysiology, we aim to discover novel ion channels and reveal their regulatory mechanism and physiological function. Through our discoveries, we strive to inspire new therapeutic strategies targeting ion channels, ultimately contributing to the treatment of diseases, such as ischemic stroke, Alzheimer's Disease, and cancer. With a strong commitment to collaboration, innovation, and mentorship, our lab seeks to empower the next generation of scientists to push the boundaries of ion channel research and beyond. 

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Qiu Lab Holiday Party 2024

Selected Recent Publications 

​Puromycin-sensitive aminopeptidase acts as an inhibitory auxiliary subunit of volume-regulated anion channels.

Zheng W, Hagino T, Wang H, Cheng HY, Koylass N, Chen KH, Wang H, Mani S, Mondal AK, Twomey EC, Qiu Z

Molecular Cell (in press). doi: 10.1101/2025.08.24.671966

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Proton-activated chloride channel governs phagosome-mediated anti-bacterial immunity in peritoneal macrophages.

Cheng HY, Chu J, Limjunyawong N, Chen J, Ye Y, Chen KH, Koylass N, Sun S, Dong X, Qiu Z

Journal of Experimental Medicine 2025. PMID: 40844458.

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Loss of proton-activated chloride channel in neurons impairs AMPA receptor endocytosis and LTD via endosomal hyper-acidification.

Chen KH, Yang J, Liu B, Jiang C, Koylass N, Zhang Z, Sun S, Huganir R, Qiu Z.

Cell Reports 2025. PMID: 39946237.

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See All Publications​

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