Qiu Lab Papers

PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel.
Yang J*, Chen J*, Vitery MDC*, Osei-Owusu J, Chu J, Yu H, Sun S, Qiu Z.
Science 2019, 364:395-399. doi: 10.1126/science.aav9739. 
*Equal contribution.

              PNAS Front Matter: Newly discovered ion channel gene promises disease insights 

Glutamate-releasing SWELL1 channel in astrocytes modulates synaptic transmission

and promotes brain damage in stroke.

Yang J, Vitery MDC, Chen J, Osei-Owusu J, Chu J, Qiu Z.

Neuron 2019. doi: 10.1016/j.neuron.2019.03.029.

Molecular Biology and Physiology of Volume-Regulated Anion Channel (VRAC).

Osei-Owusu J, Yang J, Vitery MDC, Qiu Z.

Current Topics in Membranes 2018, 81:177-203. doi: 10.1016/bs.ctm.2018.07.005.

Selected Prior Work

Structure of the human volume regulated anion channel.

Kefauver JMSaotome KDubin AEPallesen JCottrell CACahalan SMQiu ZHong GCrowley CS

Whitwam TLee WHWard ABPatapoutian A. eLife 2018. doi: 10.7554/eLife.38461.

 

Piezo2 is an airway stretch sensor mediating lung inflation-induced apnea.
Nonomura K, Woo SH, Chang R, Gillich A, Qiu Z, Francisco AG, Ranade SS, Liberles SD, Patapoutian A.
Nature 2017, 541:176-181.

LRRC8 proteins form volume-regulated anion channels that sense ionic strength.

Syeda R*, Qiu Z*, Dubin AE, Murthy SE, Florendo MN, Mason DE, Mathur J, Cahalan SM, Peters EC,

Montal M, Patapoutian A.

Cell 2016, 164: 499-511. *Equal contribution. (PDF)

SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel.

Qiu Z, Dubin AE, Mathur J, Tu B, Reddy K, Miraglia LJ, Reinhardt J, Orth AP, Patapoutian A.

Cell 2014, 157: 447-458. Cover story. (PDF) 

                Reviewed in: Science 2014, 344: 585-6; Nat Rev Mol Cell Biol 2014, 15; J Gen Physiol 2014, 143, 525-6.

                The Scientist Magazine: Key Osmotic Channel Protein Identified  

                NIH Director’s Blog: This SWELL Protein Keeps Cells in Shape

                Scripps Research Institute: Team Solves Decades-Old Mystery of How Cells Keep from Bursting 

Piezo1, a mechanically activated ion channel, is required for vascular development in mice.

Ranade SS*, Qiu Z*, Woo SH, Hur SS, Murthy SE, Cahalan SM, Xu J, Mathur J, Bandell M, Coste B, Li YS, Chien S, Patapoutian A.

PNAS 2014, 111: 10347-52. *Equal contribution. (PDF)

Piezo2 is required for Merkel cell mechanotransduction.

Woo SH, Ranade S, Weyer AD, Dubin AE, Baba Y, Qiu Z, Petrus M, Miyamoto T, Reddy K, Lumpkin EA, Stucky CL, Patapoutian A.

Nature 2014, 509: 622-6.

Piezo2 is the major transducer of mechanical forces for touch sensation in mice.

Ranade SS, Woo SH, Dubin AE, Moshourab RA, Wetzel C, Petrus M, Mathur J, Bégay V, Coste B, Mainquist J, Wilson AJ, Francisco AG, Reddy K, Qiu Z, Wood JN, Lewin GR, Patapoutian A.

Nature 2014, 516: 121-5.

c-Abl tyrosine kinase regulates cardiac growth and development.

Qiu Z, Cang Y & Goff SP.

PNAS 2010, 107: 1136-41. (PDF)

Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum.

Qiu Z, Cang Y & Goff SP.

Journal of Neuroscience 2010, 30: 14430-9. (PDF)

Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression.

Genander M, Halford MM, Xu NJ, Eriksson M, Yu Z, Qiu Z, Martling A, Greicius G, Thakar S, Catchpole T, Chumley MJ, Zdunek S, Wang C, Holm T, Goff SP, Pettersson S, Pestell RG, Henkemeyer M, Frisén J.

Cell 2009, 139: 679-692.

Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry.

Qiu Z, Hingley ST, Simmons G, Yu C, Das Sarma J, Bates P, Weiss SR.

Journal of Virology 2006, 80: 5768-76.

Characterization of five nearly full-length genomes of early HIV type 1 strains in Ruili city: implications for the genesis of CRF07_BC and CRF08_BC circulating in China.

Qiu Z, Xing H, Wei M, Duan Y, Zhao Q, Xu J, Shao Y.

AIDS Res Hum Retroviruses 2005, 21: 1051-6.

Cell