Selected Qiu Lab Papers (a full list in PubMed)
2025
Loss of proton-activated chloride channel in neurons impairs AMPA receptor endocytosis and LTD via endosomal hyper-acidification.
Chen KH, Yang J, Liu B, Jiang C, Koylass N, Zhang Z, Sun S, Huganir R, Qiu Z.
Cell Reports (in press).
bioRxiv 2024. doi: 10.1101/2024.09.27.615471
2024
Proton-activated chloride channel increases endplate porosity and pain in a mouse spine degeneration model.
Xue P, Zhang W, Shen M, Yang J, Chu J, Wang S, Wan M, Zheng J, Qiu Z*, Cao X*.
Journal of Clinical Investigation 2024 Aug 28;134(20):e168155. doi: 10.1172/JCI168155.
The SWELL1 Channel Promotes Ischemic Brain Damage by Mediating Neuronal Swelling and Glutamate Toxicity.
Chen J, Yang J, Chu J, Chen KH, Alt J, Rais R, Qiu Z.
Advanced Science 2024 Sep;11(36):e2401085. doi: 10.1002/advs.202401085.
Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in mice.
Sullivan JM, Bagnell AM, Alevy J, Avila EM, Mihaljević L, Saavedra-Rivera PC, Kong L, Huh JS, McCray BA, Aisenberg WH, Zuberi AR, Bogdanik L, Lutz CM, Qiu Z, Quinlan KA, Searson PC, Sumner CJ.
Science Translational Medicine 2024 May 22;16(748):eadk1358. doi: 10.1126/scitranslmed.adk1358.
Liu Y, Fan M, Yang J, Mihaljević L, Chen KH, Ye Y, Sun S, Qiu Z.
Science Advances 2024 May 17;10(20):eadm9326. doi: 10.1126/sciadv.adm9326.
bioRxiv 2023. https://www.biorxiv.org/content/10.1101/2024.03.26.586861v1.
Swell1 channel-mediated tonic GABA release from astrocytes modulates cocaine rewardulated anion channels.
Yang J and Qiu Z.
Neuropsychopharmacology 2024 Jan;49(1):327-328. doi: 10.1038/s41386-023-01691-4.
2023
Insights into stoichiometry and gating of heteromeric LRRC8A-LRRC8C volume-regulated anion channels.
Hagino T and Qiu Z.
Nat Struct Mol Biol 2023. 30(6):714-716. doi: 10.1038/s41594-023-01012-9.
ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain.
Chu J, Yang J, Zhou Y, Chen J, Chen KH, Zhang C, Cheng HY, Koylass N, Liu JO, Guan Y, Qiu Z.
Science Advances 2023. 9(13):eade9931. doi: 10.1126/sciadv.ade9931.
bioRxiv 2023. doi: https://doi.org/10.1101/2023.01.08.523161.
Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA.
Yang J, Chen J, Liu Y, Chen KH, Baraban JM, Qiu Z.
Neuron 2023. S0896-6273(22)01154-0. PMID: 36681074
Inhibition of the proton-activated chloride channel PAC by PIP2.
Mihaljević L, Ruan Z, Osei-Owusu J, Lü W*, Qiu Z*.
eLife 2023. 12:e83935. doi: 10.7554/eLife.83935. PMID: 36633397
bioRxiv 2022. doi: https://doi.org/10.1101/2022.10.06.511171.
2022
Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC.
Osei-Owusu J, Ruan Z, Mihaljević L, Matasic DS, Chen KH, Lü W*, Qiu Z*.
eLife 2022. 11:e82955. doi: 10.7554/eLife.82955. PMID: 36547405
bioRxiv 2022. doi: https://doi.org/10.1101/2022.08.30.505880.
Molecular determinants of pH sensing in the proton-activated chloride channel.
Osei-Owusu J, Kots E, Ruan Z, Mihaljević L, Chen KH, Tamhaney A, Ye X, Lü W, Weinstein H, Qiu Z.
PNAS 2022. 119(31):e2200727119. PMID: 35878032
Sensational astrocytes: Mechanotransduction in adult brain function.
Chen KH, Qiu Z.
Neuron 2022. 110(18):2891-2893. PMID: 36137517
An anion channel for cyclic dinucleotides in T cells.
Chu J, Qiu Z.
Nature Immunology 2022. 23(2):157-158. PMID: 35105986
2021
Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis.
Osei-Owusu J, Yang J, Leung KH, Ruan Z, Lü W, Krishnan Y, Qiu Z.
Cell Reports 2021. 34(4):108683. PMID: 33503418
2020
Structures and gating mechanism of proton-activated chloride channel.
Ruan Z*, Osei-Owusu J*, Du J, Qiu Z#, Lü W#.
Nature 2020. 588(7837):350-354. PMID: 33149300
Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity.
Zhou C, Chen X, Planells-Cases R, Chu J,...... Qiu Z*, Jentsch TJ*, Xiao H*.
Immunity 2020, 52(5):767-781. PMID: 32277911
*Corresponding authors.
Preview: Alert from a Distant Neighbor: Spread of Antiviral Immunity through Anion Channels
PAC proton-activated chloride channel contributes to acid-induced cell death in primary rat cortical neurons.
Osei-Owusu J, Yang J, Vitery MDC, Tian M, Qiu Z.
Channels 2020. doi: 10.1080/19336950.2020.1730019.
2019
PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel.
Yang J*, Chen J*, Vitery MDC*, Osei-Owusu J, Chu J, Yu H, Sun S, Qiu Z.
Science 2019, 364:395-399. doi: 10.1126/science.aav9739. *Equal contribution.
PNAS Front Matter: Newly discovered ion channel gene promises disease insights
Glutamate-releasing SWELL1 channel in astrocytes modulates synaptic transmission
and promotes brain damage in stroke.
Yang J, Vitery MDC, Chen J, Osei-Owusu J, Chu J, Qiu Z.
Neuron 2019.102: 813-827. PMID: 30982627
Preview: Swelling Gliotransmission by SWELL1 Channels
2018
Molecular Biology and Physiology of Volume-Regulated Anion Channel (VRAC).
Osei-Owusu J, Yang J, Vitery MDC, Qiu Z.
Current Topics in Membranes 2018, 81:177-203. doi: 10.1016/bs.ctm.2018.07.005.
Selected Prior Work
Structure of the human volume regulated anion channel.
Kefauver JM, Saotome K, Dubin AE, Pallesen J, Cottrell CA, Cahalan SM, Qiu Z, Hong G, Crowley CS,
Whitwam T, Lee WH, Ward AB, Patapoutian A. eLife 2018. doi: 10.7554/eLife.38461.
Piezo2 is an airway stretch sensor mediating lung inflation-induced apnea.
Nonomura K, Woo SH, Chang R, Gillich A, Qiu Z, Francisco AG, Ranade SS, Liberles SD, Patapoutian A.
Nature 2017, 541:176-181.
LRRC8 proteins form volume-regulated anion channels that sense ionic strength.
Syeda R*, Qiu Z*, Dubin AE, Murthy SE, Florendo MN, Mason DE, Mathur J, Cahalan SM, Peters EC,
Montal M, Patapoutian A.
Cell 2016, 164: 499-511. *Equal contribution. (PDF)
SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel.
Qiu Z, Dubin AE, Mathur J, Tu B, Reddy K, Miraglia LJ, Reinhardt J, Orth AP, Patapoutian A.
Cell 2014, 157: 447-458. Cover story. (PDF)
Reviewed in: Science 2014, 344: 585-6; Nat Rev Mol Cell Biol 2014, 15; J Gen Physiol 2014, 143, 525-6.
The Scientist Magazine: Key Osmotic Channel Protein Identified
NIH Director’s Blog: This SWELL Protein Keeps Cells in Shape
Scripps Research Institute: Team Solves Decades-Old Mystery of How Cells Keep from Bursting
Piezo1, a mechanically activated ion channel, is required for vascular development in mice.
Ranade SS*, Qiu Z*, Woo SH, Hur SS, Murthy SE, Cahalan SM, Xu J, Mathur J, Bandell M, Coste B, Li YS, Chien S, Patapoutian A.
PNAS 2014, 111: 10347-52. *Equal contribution. (PDF)
Piezo2 is required for Merkel cell mechanotransduction.
Woo SH, Ranade S, Weyer AD, Dubin AE, Baba Y, Qiu Z, Petrus M, Miyamoto T, Reddy K, Lumpkin EA, Stucky CL, Patapoutian A.
Nature 2014, 509: 622-6.
Piezo2 is the major transducer of mechanical forces for touch sensation in mice.
Ranade SS, Woo SH, Dubin AE, Moshourab RA, Wetzel C, Petrus M, Mathur J, Bégay V, Coste B, Mainquist J, Wilson AJ, Francisco AG, Reddy K, Qiu Z, Wood JN, Lewin GR, Patapoutian A.
Nature 2014, 516: 121-5.
c-Abl tyrosine kinase regulates cardiac growth and development.
Qiu Z, Cang Y & Goff SP.
PNAS 2010, 107: 1136-41. (PDF)
Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum.
Qiu Z, Cang Y & Goff SP.
Journal of Neuroscience 2010, 30: 14430-9. (PDF)
Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression.
Genander M, Halford MM, Xu NJ, Eriksson M, Yu Z, Qiu Z, Martling A, Greicius G, Thakar S, Catchpole T, Chumley MJ, Zdunek S, Wang C, Holm T, Goff SP, Pettersson S, Pestell RG, Henkemeyer M, Frisén J.
Cell 2009, 139: 679-692.
Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry.
Qiu Z, Hingley ST, Simmons G, Yu C, Das Sarma J, Bates P, Weiss SR.
Journal of Virology 2006, 80: 5768-76.
Characterization of five nearly full-length genomes of early HIV type 1 strains in Ruili city: implications for the genesis of CRF07_BC and CRF08_BC circulating in China.
Qiu Z, Xing H, Wei M, Duan Y, Zhao Q, Xu J, Shao Y.
AIDS Res Hum Retroviruses 2005, 21: 1051-6.
