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Selected Qiu Lab Papers (a full list in PubMed)

ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain.

Chu J, Yang J, Zhou Y, Chen J, Chen KH, Zhang C, Cheng HY, Koylass N, Liu JO, Guan Y, Qiu Z.

Science Advances (in press). 

bioRxiv 2023. doi:

Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA.

Yang J, Chen J, Liu Y, Chen KH, Baraban JM, Qiu Z.

Neuron 2023. S0896-6273(22)01154-0. Online ahead of print. PMID: 36681074.























Inhibition of the proton-activated chloride channel PAC by PIP2.

Mihaljević L, Ruan Z, Osei-Owusu J, Lü W*, Qiu Z*.

eLife 2023. 12:e83935. doi: 10.7554/eLife.83935. PMID: 36633397.

bioRxiv 2022. doi:




Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC.

Osei-Owusu J, Ruan Z, Mihaljević L, Matasic DS, Chen KH, Lü W*, Qiu Z*.

eLife 2022. 11:e82955. doi: 10.7554/eLife.82955. PMID: 36547405.

bioRxiv 2022. doi:


Molecular determinants of pH sensing in the proton-activated chloride channel.

Osei-Owusu J, Kots E, Ruan Z, Mihaljević L, Chen KH, Tamhaney A, Ye X, Lü W, Weinstein H, Qiu Z.

PNAS 2022. 119(31):e2200727119. PMID: 35878032.












Sensational astrocytes: Mechanotransduction in adult brain function.

Chen KH, Qiu Z.

Neuron 2022. 110(18):2891-2893. PMID: 36137517.

An anion channel for cyclic dinucleotides in T cells.

Chu J, Qiu Z.

Nature Immunology 2022. 23(2):157-158. PMID: 35105986.



Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis.

Osei-Owusu J, Yang J, Leung KH, Ruan Z, Lü W, Krishnan Y, Qiu Z.

Cell Reports 2021. 34(4):108683. PMID: 33503418.












Structures and gating mechanism of proton-activated chloride channel.

Ruan Z*, Osei-Owusu J*, Du J, Qiu Z#, Lü W#.

Nature 2020. 588(7837):350-354. PMID: 33149300.

Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity.

Zhou C, Chen X, Planells-Cases R, Chu J,...... Qiu Z*, Jentsch TJ*, Xiao H*. 

Immunity 2020, 52(5):767-781. PMID: 32277911. 

*Corresponding authors.

                Preview: Alert from a Distant Neighbor: Spread of Antiviral Immunity through Anion Channels 






PAC proton-activated chloride channel contributes to acid-induced cell death in primary rat cortical neurons.

Osei-Owusu J, Yang J, Vitery MDC, Tian M, Qiu Z.

Channels 2020. doi: 10.1080/19336950.2020.1730019.

PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel.
Yang J*, Chen J*, Vitery MDC*, Osei-Owusu J, Chu J, Yu H, Sun S, Qiu Z.
Science 2019, 364:395-399. doi: 10.1126/science.aav9739. 
*Equal contribution.

              PNAS Front Matter: Newly discovered ion channel gene promises disease insights












Glutamate-releasing SWELL1 channel in astrocytes modulates synaptic transmission

and promotes brain damage in stroke.

Yang J, Vitery MDC, Chen J, Osei-Owusu J, Chu J, Qiu Z.

Neuron 2019.102: 813-827. PMID: 30982627.

                 Preview: Swelling Gliotransmission by SWELL1 Channels 










Molecular Biology and Physiology of Volume-Regulated Anion Channel (VRAC).

Osei-Owusu J, Yang J, Vitery MDC, Qiu Z.

Current Topics in Membranes 2018, 81:177-203. doi: 10.1016/bs.ctm.2018.07.005.

Cover template_neuron.jpg
1200 x 1200 pixel no Arrows-01.tif
cGAMP Immunity 2020.jpg
SWELL astrocyte-neuron model.tif
Figure 3.tif
PAC 2019 Figure 1.tif
Figure 7.tif
Copy of Copy of GABA Synthesis and Uptake.png
Image for eLife 82955.png

Selected Prior Work

Structure of the human volume regulated anion channel.

Kefauver JMSaotome KDubin AEPallesen JCottrell CACahalan SMQiu ZHong GCrowley CS

Whitwam TLee WHWard ABPatapoutian A. eLife 2018. doi: 10.7554/eLife.38461.


Piezo2 is an airway stretch sensor mediating lung inflation-induced apnea.
Nonomura K, Woo SH, Chang R, Gillich A, Qiu Z, Francisco AG, Ranade SS, Liberles SD, Patapoutian A.
Nature 2017, 541:176-181.

LRRC8 proteins form volume-regulated anion channels that sense ionic strength.

Syeda R*, Qiu Z*, Dubin AE, Murthy SE, Florendo MN, Mason DE, Mathur J, Cahalan SM, Peters EC,

Montal M, Patapoutian A.

Cell 2016, 164: 499-511. *Equal contribution. (PDF)

SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel.

Qiu Z, Dubin AE, Mathur J, Tu B, Reddy K, Miraglia LJ, Reinhardt J, Orth AP, Patapoutian A.

Cell 2014, 157: 447-458. Cover story. (PDF) 

                Reviewed in: Science 2014, 344: 585-6; Nat Rev Mol Cell Biol 2014, 15; J Gen Physiol 2014, 143, 525-6.

                The Scientist Magazine: Key Osmotic Channel Protein Identified  

                NIH Director’s Blog: This SWELL Protein Keeps Cells in Shape

                Scripps Research Institute: Team Solves Decades-Old Mystery of How Cells Keep from Bursting 

Piezo1, a mechanically activated ion channel, is required for vascular development in mice.

Ranade SS*, Qiu Z*, Woo SH, Hur SS, Murthy SE, Cahalan SM, Xu J, Mathur J, Bandell M, Coste B, Li YS, Chien S, Patapoutian A.

PNAS 2014, 111: 10347-52. *Equal contribution. (PDF)

Piezo2 is required for Merkel cell mechanotransduction.

Woo SH, Ranade S, Weyer AD, Dubin AE, Baba Y, Qiu Z, Petrus M, Miyamoto T, Reddy K, Lumpkin EA, Stucky CL, Patapoutian A.

Nature 2014, 509: 622-6.

Piezo2 is the major transducer of mechanical forces for touch sensation in mice.

Ranade SS, Woo SH, Dubin AE, Moshourab RA, Wetzel C, Petrus M, Mathur J, Bégay V, Coste B, Mainquist J, Wilson AJ, Francisco AG, Reddy K, Qiu Z, Wood JN, Lewin GR, Patapoutian A.

Nature 2014, 516: 121-5.

c-Abl tyrosine kinase regulates cardiac growth and development.

Qiu Z, Cang Y & Goff SP.

PNAS 2010, 107: 1136-41. (PDF)

Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum.

Qiu Z, Cang Y & Goff SP.

Journal of Neuroscience 2010, 30: 14430-9. (PDF)

Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression.

Genander M, Halford MM, Xu NJ, Eriksson M, Yu Z, Qiu Z, Martling A, Greicius G, Thakar S, Catchpole T, Chumley MJ, Zdunek S, Wang C, Holm T, Goff SP, Pettersson S, Pestell RG, Henkemeyer M, Frisén J.

Cell 2009, 139: 679-692.

Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry.

Qiu Z, Hingley ST, Simmons G, Yu C, Das Sarma J, Bates P, Weiss SR.

Journal of Virology 2006, 80: 5768-76.

Characterization of five nearly full-length genomes of early HIV type 1 strains in Ruili city: implications for the genesis of CRF07_BC and CRF08_BC circulating in China.

Qiu Z, Xing H, Wei M, Duan Y, Zhao Q, Xu J, Shao Y.

AIDS Res Hum Retroviruses 2005, 21: 1051-6.


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